2. Signaling Pathways
  3. TGF-beta/Smad
  4. TGF-β Receptor
  5. TGF-β Receptor Degrader

TGF-β Receptor Degrader

TGF-β Receptor Isoform Comparison

TGF-β Receptor Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-161398
    TGFβRII-IN-3
    		Degrader
    TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) (IC50 = 4.1 μM). TGFβRII-IN-3 inhibits TGFβ signaling by promoting the proteolytic degradation of TGFβ RII. TGFβRII-IN-3 can block endothelial-to-mesenchymal transition and cell migration. TGFβRII-IN-3 can be used in cancer research.